3/20/2024 0 Comments Silvadene burn cream“Our data suggest a mechanism by which SSD impairs wound healing,” the authors write. RELATED: ‘Bad’ molecules found to be good for wound healing By day 10, the SSD-treated group demonstrated 16.3 percent closure compared with 42.1 closure in controls. By day three, controls and SSD-treated wounds expanded as compared to the first day-though the extent was significantly greater in the SSD-treated group (49.7 percent versus 23.8 percent). The researchers found that compared with controls, topical SSD applied to burns significantly delayed wound closure. Cytokine-signal intensity was determined using special software. Burn wounds were harvested for cytokine analysis and tissue samples were analyzed in duplicate for cytokine expression. Histologic samples were stained to visualize morphology, collagen deposition, macrophages and neutrophils. Mice were sacrificed for histology on days three, seven and 15. Daily photographs and special computer software were used to assess changes in the wound area. They began by inducing two 5 mm burns on the backs of mice, which were then split into two groups: untreated control and SSD-treated. RELATED: Nanotechnology accelerates wound healing With all that in mind, the researchers set out to determine SSD’s impact on wound healing and suggest mechanisms by which the activity occurs. The authors also acknowledge that the study involved mice, and that “the translatability of murine data to humans is questionable.” On the other hand, the authors note, several previous studies have shown that SSD performs less than spectacularly when compared with other wound-healing adjuvants. The study, conducted by researchers from the Albert Einstein College of Medicine in Bronx, N.Y., acknowledges that, as an anti-microbial agent, SSD can prevent infection and accelerate wound healing by lowering bacterial burden. A new study, however, strongly refutes SSD’s reputation-indeed, one of the study authors recommends that physicians stop using it. Fewer dressing changes combined with later skin grafting could allow burn wounds to demarcate and heal more effectively, benefiting both graft and donor sites.Silver sulfadiazine (SSD) has long been considered the gold standard for treating wounds, especially burns. 9.9d, p=0.002), with a larger proportion of these patients returning for outpatient grafting.ĬONCLUSION: These results suggest that initial treatment with a closed dressing of Xeroform gauze may promote zone of stasis healing resulting in smaller graft sizes compared to silver sulfadiazine cream. Of note, time from injury to grafting was significantly longer in the Xeroform group (24d vs. Burn TBSA and rates of skin grafting were similar between the groups however, the mean area of the skin graft was significantly smaller for the Xeroform group (147cm 2 vs. RESULTS: Three hundred forty-seven patients were included, of whom 200 were treated with silver sulfadiazine and 147 with Xeroform only. Data collected included demographics, burn total body surface area (TBSA), length of hospital stay, and necessity, size, and timing of skin grafting. METHODS: A retrospective chart review was conducted of patients age 5 years with mixed-depth scald injuries between: 1) years 2004-2008, when silver sulfadiazine was standard care, and 2) 2015-2018, when Xeroform only had become standard. The purpose of this study is to compare patient outcomes between Xeroform only and silver sulfadiazine. Over recent years, we transitioned to using closed Xeroform dressings (3% bismuth tribromophenate in petrolatum-soaked gauze) in the initial care of partial thickness burns. INTRODUCTION: Silver sulfadiazine 1% cream changed daily was historically the mainstay initial treatment at our pediatric burn center. TITLE: Xeroform gauze is superior to silver sulfadiazine cream in promoting zone of stasis healing for mixed-depth scald burns in children
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